Introduction to Theoretical Population Genetics
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Beschreibung
This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. I have tried to formulate the various models fairly generally and to state the biological as sumptions quite explicitly. I hope the choice and treatment of topics will en able the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. Models in population genetics are highly idealized, often even over idealized, and their connection with observation is frequently remote. Further more, it is not practicable to measure the parameters and variables in these models with high accuracy. These regrettable circumstances amply justify the use of appropriate, lucid, and rigorous approximations in the analysis of our models, and such approximations are often illuminating even when exact solu tions are available. However, our empirical and theoretical limitations justify neither opaque, incomplete formulations nor unconvincing, inadequate analy ses, for these may produce uninterpretable, misleading, or erroneous results. Intuition is a principal source of ideas for the construction and investigation of models, but it can replace neither clear formulation nor careful analysis. Fisher (1930; 1958, pp. x, 23-24, 38) not only espoused similar ideas, but he recognized also that our concepts of intuition and rigor must evolve in time. The book is neither a review of the literature nor a compendium of results. The material is almost entirely self-contained. The first eight chapters are a thoroughly revised and greatly extended version of my published lecture notes (Nagylaki, 1977a).
This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. The various models are formulated fairly generally and the biological assumptions are stated quite explicitly. The choice and treatment of topics enable the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. The material suffices for a one-year course and is almost entirely self-contained. The problems are an essential part of this book. Although some of them ask the reader merely to supply details of derivations in the text, many illuminate, rigorize, or extend these derivations. Some of the results in the problems are useful and important.
Autor*in
Thomas Nagylaki
Themen in »Introduction to Theoretical Population Genetics«
Random genetic drift algebra biological breeding dynamics genetics mathematical method migration mutation population population genetics selection