Drosophila Eye Development
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Beschreibung
The compound eye of Drosophila is used as a model for human disease and homology to eyes in other taxa. This book covers the major discoveries on the development of the compound eye of Drosophila melanogaster over the last 25 years. These include aspects of the biological mechanisms of pattern formation in the nervous system, the specification of neuronal cell types, unexpected phylogenetic conservation and many new insights into the function of several signal transduction pathways. All chapters in this book have been written by leading experts in this field who have made significant contributions to our understanding of fly eye development.
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Comprehensive and detailed descriptions of one of the best understood models for nervous system development Authors are all leading experts in the field Unique survey on the cellular and developmental biology of eye development, its evolutionary history and its use in human disease modeling Includes supplementary material: sn.pub/extras
Autor*in
Kevin Moses
Themen in »Drosophila Eye Development«
Activation DNA Drosophila Eye Genetics Genetik Invertebrate Signalübertragung Termination Vertebrate conservation genes growth cones regulation signal transduction