Cooperation of Liver Cells in Health and Disease
Buch in deiner Nähe kaufen
Beschreibung
The book is the first monograph that describes the importance of the interactions between hepatocytes and nonparenchymal liver cells for the functions of both normal and diseased liver. The concise description of major types of non-hepatocytes (sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes) has been followed by the presentation of the role of cellular cross-talks for the physiological regulation of specific liver functions such as uptake and storage of vitamin A, modulation of glucose homeostasis, sinusoidal blood flow regulation, synthesis of eicosanoids, nitric oxide, and growth factors. The functioning of complicated intercellular networks during the course of endotoxin-induced liver damage, and development of liver fibrosis has also been presented.
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Autor*in
Z. Kmiec
Themen in »Cooperation of Liver Cells in Health and Disease«
Kupffer cells Liver cell cooperation cells endothelium endotoxic liver injury hepatic stellate cells intrahepatic lymphocytes liver fibrosis nonparenchymal liver cells physiology regulation hepatology