Acute Promyelitic Leukemia
Molecular Genetics, Mouse Models and Targeted Therapy
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Beschreibung
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Autor*in
Pier Paolo Pandolfi
Themen in »Acute Promyelitic Leukemia«
All-trans retinoic acid (ATRA) Chromosom Small ubiquitin-like modifier (SUMO) clinical trial genes genetics leukemia microRNA molecular genetics peptides protein proteins targeted therapy transcription translation