Protein Degradation / Protein Degradation Series / Protein Degradation

Beschreibung

The first volume in a new series dedicated to protein degradation, this book explains the fundamentals of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad overview of protein degradation and its functions in cellular regulation, it then goes on to discuss the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated; this includes latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, the roles of the ubiquitin pathway in regulating key cellular processes, and its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

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R. John Mayer

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Biochemie Biowissenschaften Chemie Chemistry Life Sciences Molecular Biology Molekularbiologie Protein Science Proteine

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"2004 erhielten Aaron Ciechanover, Avram Hershko und Irwine Rose den Nobelpreis für Chemie, als Anerkennung Ihrer Arbeiten zum Ubiquitin gesteuerten Proteinabbau. Der israelische Biochemiker Aaron Ciechanover vom Israel Institute of Technology in Haifa, hat sein gesammeltes Know-How zum Proteinabbau nun in Form eines mehrbändigen Werkes herausgegeben." Laborjournal
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