Mathematical Modeling of Protein Complexes
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Beschreibung
This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account.
At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.
This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account.
At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.
Applies computational methods to simulate the electrostatic interaction of protein molecules to form complexes and domains Predicts amino acid sequences with specific physical properties Helps to improve the efficiency of experiments
Autor*in
Tatiana Koshlan
Themen in »Mathematical Modeling of Protein Complexes«
Protein Domain Binding Effect of Phosphorylation on binding of proteins Calculation of Reactivity of Proteins Temperature Dependence Protein Complexes Salt Dependence Protein Complexes Amino Acids and Proteins Histone Dimer Formation Binding of Monomeric Proteins Phosphorylation Effect Simulation of Protein Complex Formation Protein Structure
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“It is to be expected that the monograph will be of interest to researchers in the field of applied proteomics who possess an aptitude for mathematical modelling and numerical simulation.” (Nikola Popovic, zbMATH 1470.92004, 2021)
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