Molecular, Cellular, and Tissue Engineering of the Vascular System
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Beschreibung
This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer’s disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.
Reviews the latest views in microvascular transport
Covers the state-of-the-art research in transport across the blood-brain barrier as well as new findings related to the endothelial surface glycocalyx as a mechanosensor to blood flow
Presents mathematical models for interactions between circulating cells and endothelial cells forming the microvessel wall
Reviews the latest literature in vascular systems from a view of biomedical engineers Covers the state-of-the-art research in endothelial surface glycocalyx, in nuclear envelope proteins, and in smooth muscle cell and surrounding extracellular matrix in maintaining vascular functions, in vulnerable plaque and abdominal aortic aneurysm, in transport across the blood-brain barrier, and in vascular system in response to temperature changes Presents mathematical models for blood cell movement and interactions between circulating cells and endothelial cells forming the microvessel wall
Autor*in
Bingmei M. Fu
Themen in »Molecular, Cellular, and Tissue Engineering of the Vascular System«
microvascular transport blood-brain barrier interactions circulation endothelial cells endothelial surface glycocalyx barrier endothelial barrier water transport endothelial surface glycocalyx mechanosensor mechanosensing mechanoregulation extracellular matrix atherosclerotic plaque microcalcifications models thermal regulation cell abdominal aortic aneurysms