Decoding Neural Circuit Structure and Function
Cellular Dissection Using Genetic Model Organisms
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Beschreibung
This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes.
Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden
tified circuit elements contribute to visual perception and behavior.Focuses on the interdisciplinary nature of modern neural circuit dissection: high-resolution anatomy, cellular activity, and behavioral dissection, to assign specific functions to identified, single neurons
Compares the progress from vertebrate and invertebrate model systems, both of which provide important, and complementary insights into circuit function
Summarizes the most recent work in a very rapidly evolving field: the use of genetic model systems that allow for the manipulation of neural circuits in vivo
Focuses on the interdisciplinary nature of modern neural circuit dissection: high-resolution anatomy, cellular activity, and behavioral dissection, to assign specific functions to identified, single neurons Compares the progress from vertebrate and invertebrate model systems, both of which provide important, and complementary insights into circuit function Summarizes the most recent work in a very rapidly evolving field: the use of genetic model systems that allow for the manipulation of neural circuits in vivo Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras
Autor*in
Arzu Çelik
Themen in »Decoding Neural Circuit Structure and Function«
Neural circuitry Bbehavior Function Genetic dissection In vivo-imaging