DNA Methyltransferases - Role and Function
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Beschreibung
DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-havefor advanced researchers in the field of DNA methylation and epigenetics.
DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-havefor advanced researchers in the field of DNA methylation and epigenetics.
Offers comprehensive insights into the newest findings in the field of DNA methylation Provides in depth knowledge on the structure, enzymatic mechanism as well as the biological roles of DNA methyltransferases Discusses related processes like reading of DNA methylation and DNA demethylation Broadens the understanding on the role of DNA methyltransferases in human diseases Chapters written by leading experts in the field Includes supplementary material: sn.pub/extras
Autor*in
Albert Jeltsch
Themen in »DNA Methyltransferases - Role and Function«
DNA methylation Epigenetics Methyltransferase Demethylation DNA labelling Cancer Therapeutic targets control of gene expression Chromatin Genome imprinting Epigenetic editing Cellular memory Biomarkers Reader proteins Emerging technologies