Imaging Biomarkers
Development and Clinical Integration
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Beschreibung
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Examines all aspects of the development of imaging biomarkers and their integration into clinical practice Includes practical use cases on imaging biomarker implementation in various fields of medicine Written by a multidisciplinary team of expert radiologists and engineers Includes supplementary material: sn.pub/extras
Autor*in
Luis Martí-Bonmatí
Themen in »Imaging Biomarkers«
Biomedical Engineering Image Processing Imaging Biomarker Development Imaging Biomarkers Measurements Multi-variate analysis Parametric Images Quantitative Radiology Precision Medicine in Imaging Imaging Biobanks
Stimmen zu »Imaging Biomarkers«
“This book discusses all the aspects of establishing an imaging biomarker by systemically guiding the reader through the various steps of development. … a book that will provide an excellent induction for novices in this field. For someone contemplating developing a new biomarker to measure a disease process of interest, or for industry employees entering the world of monitoring new treatments using biomarkers, this book will be an excellent reading and stimulate further thinking.” (Professor Frederik Barkhof, RAD Magazine, December, 2017)
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