Efflux-Mediated Antimicrobial Resistance in Bacteria
Mechanisms, Regulation and Clinical Implications
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Beschreibung
This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation andphysiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
Critical examinations of multidrug efflux systems elucidate their role in high-level antimicrobial resistance Explores the complexity of resistance mechanisms through interplay with other key resistance pathways Discusses implications for drug and adjuvant development in promoting stewardship on antimicrobial therapy Provides comprehensive, updated descriptions that enhance the reader’s biochemical understanding of multidrug efflux pumps
Autor*in
Xian-Zhi Li
Themen in »Efflux-Mediated Antimicrobial Resistance in Bacteria«
Antibiotic Antimicrobial Multidrug Pump Transporter MDR ABC MATE MFS RND SMR Chromosome Plasmid Enterobacteriaceae Acinetobacter
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“This extraordinarily comprehensive book covers the efflux pumps of several important bacterial genera regarding types of pumps, regulation of the pumps, and contribution of the pumps to antibiotic resistance. … audience includes anyone in the scientific field of antibiotic resistance. … appropriate for students and seasoned researchers. Infectious disease physicians also may find it helpful with respect to mechanisms of resistance and antibiotic stewardship. … I am not aware of a more comprehensive book on efflux‐mediated resistance than this one.” (Nancy D. Hanson, Doody's Book Reviews, February, 2017)
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