Alternating Electric Fields Therapy in Oncology
A Practical Guide to Clinical Applications of Tumor Treating Fields
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Beschreibung
This concise text provides a complete overview of alternating electric fields therapy -- also known as tumor treating fields -- for glioblastoma and other types of solid tumor malignancies. Readers are given a fundamental understanding of this novel anti-cancer treatment modality by learning from clinical trial data as well as the physical and cell biology effects on tumor cells when alternating electric fields are applied both in vitro and in vivo.
Chapters illustrate the physics
behind electric field propagation in space and other media. This is
followed by a review of our current understanding of the electric field effects
on dividing cells - including the disruption of cytokinesis, proper chromosome
segregation and activation on the cell surface chaperons that induce
immunogenic cell death. Data from phase III trials for the treatment of
recurrent and newly diagnosed glioblastomas are included, as well as some of
the ancillary post hoc analyses thatwere performed by various
investigators. The remainder of the chapter covers other solid tumor
malignancies, including non-small cell lung cancer, pancreatic cancer and
ovarian cancer, as this treatment modality is being applied to systemic
malignancies.
Alternating Electric Fields
Therapy in Oncology offers oncologists,
neurologists, radiation oncologists, biomedical engineers, cell biologists and
mitosis researchers the fundamentals needed for clinical practice.
This concise text provides a complete overview of alternating electric fields therapy -- also known as tumor treating fields -- for glioblastoma and other types of solid tumor malignancies. Readers are given a fundamental understanding of this novel anti-cancer treatment modality by learning from clinical trial data as well as the physical and cell biology effects on tumor cells when alternating electric fields are applied both in vitro and in vivo.
Chapters illustrate the physics behind electric field propagation in space and other media. This is followed by a review of our current understanding of the electric field effects on dividing cells - including the disruption of cytokinesis, proper chromosome segregation and activation on the cell surface chaperons that induce immunogenic cell death. Data from phase III trials for the treatment of recurrent and newly diagnosed glioblastomas are included, as well as some of the ancillary post hoc analyses thatwere performed by various investigators. The remainder of the chapter covers other solid tumor malignancies, including non-small cell lung cancer, pancreatic cancer and ovarian cancer, as this treatment modality is being applied to systemic malignancies.
Alternating Electric Fields Therapy in Oncology offers oncologists, neurologists, radiation oncologists, biomedical engineers, cell biologists and mitosis researchers the fundamentals needed for clinical practice.
A complete overview of alternating electric fields therapy in clinical practice Covers the therapeutic application for a variety of malignancies Written for a broad audience that includes clinicians, biomedical engineers and mitosis researchers Includes supplementary material: sn.pub/extras
Autor*in
Eric T. Wong
Themen in »Alternating Electric Fields Therapy in Oncology«
alternating electric fields therapy anti-cancer treatment glioblastomas neuro-oncology non-small cell lung cancer ovarian cancer pancreatic cancer