Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems
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Beschreibung
The book
presents a new, powerful model of neuronal networks, consisting of a
three-dimensional neuronal culture in which 3D neuronal networks are coupled to
micro-electrode-arrays (MEAs). It discusses the main advantages of the
three-dimensional system compared to its two-dimensional counterpart, and shows
that the network dynamics, recorded during both spontaneous and stimulated
activity, differs between the two models, with the 3D system being better able
to emulate the in vivo behaviour of neural networks. The book offers an
extensive analysis of the system, from the theoretical background, to its
design and applications in neuro-pharmacological studies. Moreover, it
includes a concise yet comprehensive introduction to both 2D and 3D neuronal
networks coupled to MEAs, and discusses the advantages, limitations and
challenges of their applications as cellular and tissue-like in vitro experimental model systems.
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The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.
Nominated as an outstanding PhD thesis by the University of Genoa, Italy Presents a powerful in vitro model of neuronal network dynamics implementation of bio-hybrid microsystems for network electrophysiology Includes supplementary material: sn.pub/extras
Autor*in
Monica Frega
Themen in »Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems«
Neuronal Networks Coupled to MEAs 3D Hippocampal Neuronal Networks MEA for Network Electrophysiology Micro-beads Based Scaffold 2D vs 3D Neuronal Networks Homogenous Neuronal Networks Patterned Neuronal Networks Spontaneous Neural Activity Stimulus-evoked Neural Activity Bio-hybrid Microsystems