Epigenetic Advancements in Cancer
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Beschreibung
This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.
This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.
Explores epigenetic landscape that occur in various cancer cells and the role of these changes in cancer initiation and progression Discusses recent technological advancements that allow epigenetic alterations in cancer to be studied across the entire genome Covers a spectrum of human cancers, including prostate, ovarian, breast, gastric, pancreatic, and more
Autor*in
Manoj K. Mishra
Themen in »Epigenetic Advancements in Cancer«
DNA methylation Gene-expression control Histone modifications RNA expression Epigenetic regulators gene expression