Long Non-coding RNAs in Human Disease
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Beschreibung
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Summarizes the tremendous progress made within the last decade in understanding the roles of lncRNA in Bridges the divide between inferring lncRNA mechanisms and targeting lncRNAs by means of rational therapeutics Stresses the vital role of lncRNA disease mechanisms for a necessary and profound reassessment of Genome-Wide Association studies in the new era of personalized medicine Includes supplementary material: sn.pub/extras
Autor*in
Kevin V. Morris
Themen in »Long Non-coding RNAs in Human Disease«
T-cell mediated immunity Cellular stress response Epigenetic loss-of-function disease Nuclear hormone receptors Prostrate cancer Tumor suppressor genes LncRNA Pseudogene-expressed RNAs Exosome associated lncRNAs ANRIL Polycomb Pseudogene-expressed RNAs Non-protein-coding transcriptome