This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Aging Disorders and Cancer are two of the best funded and highest profile scientific areas; stem cells, microvesicles (exosomes) and microRNA are at the forefront of these areas
The assembled contributors reflect worldwide perspective and expertise
Essential for those in industry as well as academic-based research
Karl L. Mettinger
Extracellular vesicles Mesenchymal stem cells miRNA Tissue engineering Tumor biomarkers
“The book contains some basic introductory material that is useful for students/researchers who are new to this area of research, … concisely written and provide a useful collection of references for readers who want to delve into some of the topics in further detail. The excellent figures and summary tables throughout the book help readers to comprehend the material.” (Michael J. Fay,Doody's Book Reviews, May 24, 2019)
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