A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
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Beschreibung
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
First book to explore different aspects of systems biology and their application to the development of the adverse outcome pathway frameworkCombines all computational and molecular tools together for applicationsBridges multiple scales of biological organization,beyond the organism to include population level effects
First book to explore different aspects of systems biology and their application to the development of the adverse outcome pathway framework Combines all computational and molecular tools together for applications Bridges multiple scales of biological organization,beyond the organism to include population level effects
Autor*in
Natàlia Garcia-Reyero
Themen in »A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment«
AOP Ecotoxicological Metabolomics Molecular Proteomics Transcriptomics Systems Biology