A Network-Based Approach to Cell Metabolism
From Structure to Flux Balances
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Beschreibung
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.
The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.
Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec
ts of the networks themselves to the balance of biochemical fluxes.
Nominated as an outstanding Ph.D. thesis by the University of Barcelona, Spain
Unveils new mechanisms and responses impossible to demonstrate with by traditional reductionist procedures
Has given rise to a large number of articles in scholarly journals
Nominated as an outstanding Ph.D. thesis by the University of Barcelona, Spain Unveils new mechanisms and responses impossible to demonstrate with by traditional reductionist procedures Has given rise to a large number of articles in scholarly journals Includes supplementary material: sn.pub/extras
Autor*in
Oriol Güell
Themen in »A Network-Based Approach to Cell Metabolism«
Chemical Biology Physical Chemistry Metabolic Networks Complex Networks Flux Balance Analysis biochemical engineering Systems Biology systems biology