Chromatin Regulation of Early Embryonic Lineage Specification
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Beschreibung
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
Examines the roles of early acting chromatin regulators in ICM and TE formation Explores the role of RHOA subfamily of small GTPases and RHO-associated coiled-coil kinases Provides an overview on the transcriptional and epigenetic mechanisms that mediate PE lineage formation and XEN cell self-renewal Includes supplementary material: sn.pub/extras
Autor*in
Jason Knott
Themen in »Chromatin Regulation of Early Embryonic Lineage Specification«
extraembryonic primitive endoderm pluripotent epiblast embryonic chromatin structure CHD1 CHD4 H3R26me SOX2-DNA