The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.
Includes tips on how to apply genome differences in personalized medicine
Provides a road map for studying cancer and degenerative disease: two sides of the same coin
Each chapter includes 10 takeaway messages to help the reader to learn quickly
Sherif El-Khamisy
Cancer DNA repair Degenerative disorders Genome instability Personalised Medicine