Genome Editing in Neurosciences
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Beschreibung
This book is open access under a CC BY 4.0 license.
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
This book is open access under a CC BY 4.0 license.
CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.
This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Highlights how genome editing is enabling breakthroughs in how we study the brain Identifies a powerful method to understand and treat central nervous system disorders Reveals system-level insight into how the nervous system develops and functions Includes supplementary material: sn.pub/extras
Autor*in
Rudolf Jaenisch
Themen in »Genome Editing in Neurosciences«
CRISPR-Cas9 genetic engineering recombinant-DNA methods double-strand breaks Ciona intestinalis isogenic IPSCs Parkinson's disease Huntington's disease Rett syndrome Duchenne muscular dystrophy Open Access