Human Chromosome Atlas
Introduction to diagnostics of structural aberrations
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Beschreibung
This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.
This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.
Offers a practical approach to modern cytogenetics
Presents a variety of different techniques, such as direct preparation of cells and mitoses, short or long time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray, and DNA sequencing
Is richly illustrated with 275 figures and color photographs
Includes supplementary material: sn.pub/extras
Autor*in
Claudia Behrend
Themen in »Human Chromosome Atlas«
Chromosome rearrangements Heteromorphisms Chromosome analyses by banding techniques FISH Genetic counselling