Alternatives for Dermal Toxicity Testing
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Beschreibung
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the useof alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques.
Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
Provides in-depth information on the alternatives to animal testing
Identifies the most suitable test method(s) for specific uses and endpoints
Describes the regulatory acceptance, protocols, performance, limitations, and applicability of each method
Explains the role of individual methods within testing strategies
Provides in-depth information on the alternatives to animal testing Identifies the most suitable test method(s) for specific uses and endpoints Describes the regulatory acceptance, protocols, performance, limitations, and applicability of each method Explains the role of individual methods within testing strategies
Autor*in
Chantra Eskes
Themen in »Alternatives for Dermal Toxicity Testing«
Alternatives to animal testing Cosmetics In vitro toxicology Regulatory testing Safety testing