Adhesion G Protein-coupled Receptors
Molecular, Physiological and Pharmacological Principles in Health and Disease
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Beschreibung
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Covers the latest progress in the understanding of the molecular events governing the signaling of Adhesion GPCRs, a large group of enigmatic receptors in the GPCR superfamily, and their physiological properties Discusses the newly discovered activation mode of Adhesion GPCRs and their metabotropic activity profile Highlights the evidence suggesting that Adhesion GPCRs detect mechanical stimuli
Autor*in
Tobias Langenhan
Themen in »Adhesion G Protein-coupled Receptors«
Cell-cell interaction Cell-matrix interaction G protein-coupled receptors Mechanoreception Metabotropic pathways