Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
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Beschreibung
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Nominated as an outstanding PhD thesis by Duke University Provides a comprehensive review of electrophilic aminations using O-benzoylhydroxylamines Presents results which are relevant for medicinal chemistry, drug discovery and materials science Includes supplementary material: sn.pub/extras
Autor*in
Stacey L. McDonald
Themen in »Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds«
Electrophilic Amination Aryl Amines Copper-Catalyzed Amination C–H Functionalization C–N Bond Formation Alpha-Aminophosphonic Acids