OCT in Central Nervous System Diseases
The Eye as a Window to the Brain
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Beschreibung
This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.
As well as being a valuable tool for diagnosis of many retinal diseases and monitoring of surgical and medical treatment, OCT allows study of the retinal nerve fiber layer (RNFL) containing the axons of the retinal ganglion cells, which form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. It is for this reason that OCT has been applied in various areas of neurology over the past decade, becoming a hot topic and generating great enthusiasm among neurologists and ophthalmologists. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
Describes the role of OCT in evaluating disease progression in neurodegenerative disorders Covers a wide range of disorders Documents recent advances and explains their significance
Autor*in
Andrzej Grzybowski
Themen in »OCT in Central Nervous System Diseases«
Neurodegenerative Diseases Optic Neuropathy Optical Coherence Topography RNFL Retinal Nerve Fiber Layer
Stimmen zu »OCT in Central Nervous System Diseases«
“The book is useful for all (neuro)ophthalmologists, and neurologists interested in the optic neuropathies and more generalized neurodegeneration. … OCT technology enables accurate measurement of the important retinal structures involved in CNS diseases, and the present book helps the reader to find his/her way through the important findings based on OCT studies. These findings are certainly helpful in the diagnostic work-up of these patients, but perhaps as yet are not sensitive enough.” (Frank Verbraak, Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 255, 2017)
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