Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
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Beschreibung
This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world’s foremost cancer research institutions.
This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world’s foremost cancer research institutions.
Presents the latest developments in personalized medicine clinical trials in oncology Describes the design and implementation of the SHIVA trial launched by the Curie Institute, France Shows the latest statistical models for high-throughput molecular techniques, bioinformatics and the challenges for their implementation in daily practice
Autor*in
Christophe Le Tourneau
Themen in »Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine«
Bioinformatics Cancer personalized medicine High throughput screening techniques Predictive biomarkers