Cardiac Management of Oncology Patients
Clinical Handbook for Cardio-Oncology
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Beschreibung
In recent years, progress in oncologic therapy has achieved important goals and a consequent prognostic improvement for patients with malignancy, but cardiac toxicity is often a concern and can have long-term functional or structural effects on the heart. This book is written for the cardiologist working in a clinical environment without support from a specific specialized cardio-oncologist team, and who are called to perform a clinical consultation to evaluate a cardiac condition and the eligibility for a patient to receive chemotherapy or radiotherapy. Cardiac Management of Oncology Patients: Clinical Handbook for Cardio-Oncology is also designed for oncologists and cardiologists to evaluate if a cancer treatment has produced toxic effects on a patient who has either recently or historically been treated with chemo or radiotherapy. The reader will discover more about the cardiac damage potentially created by the oncologic therapy that they are considering for the treatment of their patients.
This book is designed for clinical cardiologists and other physicians working with cardiac patients, where specific specialized teams of cardio-oncologists are not available and who are called to perform a clinical consultation to evaluate both the cardiac condition and the eligibility for chemotherapy or radiotherapy treatment, and to evaluate if a cancer treatment produces toxic effects on a patient treated with chemo or radiotherapy and if appearance of new symptoms is due to this treatment. In recent years, progress in oncologic therapy has resulted in important developments and the prognostic improvement of patients with malignancy. The cornerstone of chemotherapy are the anthracyclines (and the analogue Mitoxantrone), that are direct cellular toxic agents and that are among the most powerful anti-neoplastic drugs, but their cardiac toxicity is well known. Significant breakthroughs in cancer therapy have also been achieved with the introduction of signalling inhibitors, such as VEGF inhibitors, HERB2 inhibitors or TK inhibitors used alone or in combination with direct cellular toxic drugs. However, these signalling inhibitors may interact also with cardiovascular signalling and therefore may have functional or structural effects on the myocardium. This can be permanent or reversible, with impairment of the global conditions and important side effects, and increase both morbidity and mortality and worsening of quality of life. Chemotherapy and radiotherapy can have acute detrimental effects that can be present for years after treatment and that can lead to cardiac consequences also after long periods of no clinic sequelae. Patient numbers with cancer problems will dramatically increase in the next years and thus every cardiologist will need to have the correct information and the skills to manage these situations in the correct way. This book will provide these tools for them.
Practical, rapid-reference pocketbook to assist physicians in managing oncology patients in the cardiology clinic Thorough clinical review of the issues Contains tips and tricks to assist patient’s management
Autor*in
Gonzalo Baron Esquivias
Themen in »Cardiac Management of Oncology Patients«
Anthracyclines Cardio-Oncology Cardiotoxicity Chemotherapy Radiotherapy Radiaton Oncology