Iron Acquisition by the Genus Mycobacterium
History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
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Beschreibung
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Demonstrates how iron sources can be used by Mycobacterium tuberculosis and other mycobacteria
Autor*in
B. Rowe Byers
Themen in »Iron Acquisition by the Genus Mycobacterium«
Antibiotic Development Haem Iron Heme Iron Iron Sources Organisms M. Tuberculosis Mycobacterial Disease Siderocalin Enterobactin Siderophores Iron Transporter Protein-Ligand Interactions infectious diseases