The two-volume set on C-1 Building Blocks in Organic
Synthesis critically reviews the state of the art of a wide variety of reactions
by which one carbon atom is added to an organic molecule, forming a C-C bond. In
spite of the numerous classic reactions of this kind, there has been enormous
progress in recent years, especially for those reactions involving catalytic
methods. Introduction of substituted methyl groups is a major challenge and only
very recently the first catalysts have been discovered that enable the
introduction of fluoromethyl groups in aromatics.
Piet W.N.M. van Leeuwen
ALKOXYCARBONYLATION CYCLOPROPANATION METATHESIS TRIFLUOROMETHYLATION TEBBE CARBOXYLATION SYNTHETIC TRANSFORMATION KHARASCH REACTION METHOD NITROMETHANE KETONES CROSS COUPLING METHODS AZIRIDINES MANNICH TYPE REACTIONS C-1 UNIT