Activation-Induced Deaminase

Beschreibung

The mechanism of hypermutation, the process needed for B cell affinity maturation, is one of the last great mysteries in molecular biology. Activation-induced deaminase (AID) is absolutely required for hypermutation, but the mechanism by which it is recruited specifically to antibody-encoding genes remains enigmatic. This book summarizes the research on AID in the context of its central role in the affinity maturation of B cells.

Autor*in

Andrew Franklin

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Immune response B cells Hypermutation Affinity maturation Antibody

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