Hurdles for Phage Therapy (PT) to Become a Reality
Buch in deiner Nähe kaufen
Beschreibung
Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.
Autor*in
Harald Brüssow
Themen in »Hurdles for Phage Therapy (PT) to Become a Reality«
Staphylococcus aureus bacteriophage phage therapy vB_SauM-fRuSau02 Twortlikevirus antibiotic antimicrobial resistance magistral preparation compounding pharmacy phage therapy regulatory framework personalized medicine bacteriophage phage horizontal gene transfer