TRP Channels in Health and Disease
Buch in deiner Nähe kaufen
Beschreibung
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.
Autor*in
Alexander Dietrich
Themen in »TRP Channels in Health and Disease«
ion channel TRPC small molecules calcium chemical probes TRPV1 TRPV2 TRPV3 TRPV4 mucosal epithelium ulcerative colitis inflammatory bowel disease TRPM4 channel cardiovascular system physiology