Ibuprofen: Pharmacology, Therapeutics and Side Effects
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Beschreibung
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Emphasis on the scientific evidence for safety of ibuprofen especially at OTC dosage Critical reviews of recent clinical trails Written in a general style, easy to understand for a broader readership The author is an internationally recognized expert in the field of inflammation and pharmacology of anti-rheumatic and anti-inflammatory drugs Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras
Autor*in
K. D. Rainsford
Themen in »Ibuprofen: Pharmacology, Therapeutics and Side Effects«
Analgesic drugs Anti-inflammatory drugs Gastro-intestinal toxicity Hepatic toxicity Non-steroidal anti-inflammatory drugs Renal toxicity
Stimmen zu »Ibuprofen: Pharmacology, Therapeutics and Side Effects«
From the reviews:
“This book is intended for a broad readership -- anyone interested in the properties, actions, and uses of ibuprofen. This book serves this aim very well … . The book is of great value for anyone who wants to understand the historical development and clinical utility of a very popular nonsteroidal anti-inflammatory drug (NSAID) … . This is an outstanding historical and factual account of ibuprofen, one of the most widely used analgesic/antipyretic/anti-inflammatory drugs today.” (Thomas L. Pazdernik, Doody’s Book Reviews, May, 2013)
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