BioLuminescent OptoGenetics
Molecular Control with Biological Light
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Beschreibung
This book provides an overview of and introduction to the use of bioluminescence for controlling light-sensing molecules. Different from the standard use of bioluminescence in imaging applications in vitro and in vivo, bioluminescent optogenetics harnesses molecularly produced light to activate the wide range of light-controllable modules available, from ion channels to transcription factors. The book covers the principal biological mechanisms of light emission and light sensing and the palette of tools enabled when combining genetically encoded light production with light sensing for use within and across cells. Through examples covering the main applications, Bioluminescent Optogenetics provides a practical guide for using this powerful platform for neuroscience and beyond.
This book provides an overview of and introduction to the use of bioluminescence for controlling light-sensing molecules. Different from the standard use of bioluminescence in imaging applications in vitro and in vivo, bioluminescent optogenetics harnesses molecularly produced light to activate the wide range of light-controllable modules available, from ion channels to transcription factors. The book covers the principal biological mechanisms of light emission and light sensing and the palette of tools enabled when combining genetically encoded light production with light sensing for use within and across cells. Through examples covering the main applications, Bioluminescent Optogenetics provides a practical guide for using this powerful platform for neuroscience and beyond.
Describes the critical principles and molecules used in bioluminescent optogenetic tools Introduces the key principles of control and integration of biological processes enabled by bioluminescent optogenetics Highlights applications of bioluminescent optogenetic tools in neuroscience
Autor*in
Ute Hochgeschwender
Themen in »BioLuminescent OptoGenetics«
bioluminescence BL-OG luciferase luciferin light stimulation optogenetic tools photoreceptor channelrhodopsins LOV domain