Nanocrystals
A Universal Tool for the Formulation of Poorly Soluble Drugs
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Beschreibung
Nanocrystals have emerged as one of the most versatile and clinically relevant platforms for the delivery of poorly soluble drugs, with several nanocrystal-based products already on the market. Produced through both “bottom-up” and “top-down” approaches, drug nanocrystals possess a large specific surface area that enhances the dissolution and absorption of hydrophobic actives, offering a powerful strategy to improve drug performance. This book presents the fundamental principles of nanocrystal technology alongside their broad applications in modern drug delivery. Chapters explore oral bioavailability enhancement, long-acting injectable therapies, topical and transdermal delivery (including microneedles), ocular and mucosal administration, pulmonary delivery, and strategies for targeting the central nervous system. Each contribution highlights both the opportunities and the challenges of applying nanocrystal formulations across therapeutic areas. Intended for drug delivery scientists in both academia and industry, this volume provides a comprehensive overview of nanocrystal research, development, and translation into innovative therapeutic solutions. By combining rigorous science with insights into clinical and commercial impact, it serves as a valuable resource for researchers, students, and professionals aiming to harness nanocrystals in addressing complex therapeutic needs.
Nanocrystals have emerged as one of the most versatile and clinically relevant platforms for the delivery of poorly soluble drugs, with several nanocrystal-based products already on the market. Produced through both “bottom-up” and “top-down” approaches, drug nanocrystals possess a large specific surface area that enhances the dissolution and absorption of hydrophobic actives, offering a powerful strategy to improve drug performance. This book presents the fundamental principles of nanocrystal technology alongside their broad applications in modern drug delivery. Chapters explore oral bioavailability enhancement, long-acting injectable therapies, topical and transdermal delivery (including microneedles), ocular and mucosal administration, pulmonary delivery, and strategies for targeting the central nervous system. Each contribution highlights both the opportunities and the challenges of applying nanocrystal formulations across therapeutic areas. Intended for drug delivery scientists in both academia and industry, this volume provides a comprehensive overview of nanocrystal research, development, and translation into innovative therapeutic solutions. By combining rigorous science with insights into clinical and commercial impact, it serves as a valuable resource for researchers, students, and professionals aiming to harness nanocrystals in addressing complex therapeutic needs.
Covers the formulation and manufacturing techniques of poorly soluble drugs using various approaches with nanocrystals Reveals the various platforms where nanocrystals have been enabled in the management of multiple diseases Discusses the evolution of nanocrystal technologies and the advancements of nanocrystal-based products on the market
Autor*in
Alejandro J. Paredes
Themen in »Nanocrystals«
Nanocrystals Nanosuspensions Drug delivery Hydrophobic drugs Poorly soluble drugs Nanoparticles Manufacturing techniques Parenteral administration Microneedle-mediated administration Mucosal tissues Management of ocular diseases Nanocrystal technology Pharmaceutical industry Drug formulation Enhancing the absorption of poorly soluble drugs