mTOR Signaling in Ophthalmology

Beschreibung

Recent advances in research have identified the mTOR signaling pathway as a promising therapeutic target for numerous ocular diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, and more. These conditions share common pathological features, such as oxidative stress, which leads to damage of key retinal cells like photoreceptors, retinal ganglion cells (RGCs), and retinal pigment epithelium (RPE). The mTOR pathway plays a crucial role in regulating oxidative stress but is also influenced by reactive oxygen species (ROS). Understanding this intricate relationship is essential for developing new treatments for retinal degeneration.

This book emphasizes the role of mTOR-mediated autophagy (recycling) in the pathogenesis of many of these diseases, with a particular focus on the therapeutic potential of rapamycin, an mTOR inhibitor, across various ocular conditions. With extensive insights from both basic and clinical research, the book explores the potential of mTORC1 inhibition for example in slowing myopia progression, as well as rapamycin's application in conditions like Graves ophthalmopathy, dry eye, uveitis, Sjogren’s syndrome, geographic atrophy, and ocular solid tumors.

For the first time, this book compiles key findings on the influence of mTOR signaling in ocular diseases, making it an invaluable resource for researchers, medical professionals, students, and those in the ophthalmology industry. It provides a comprehensive overview of the therapeutic potential of targeting mTOR in eye diseases, offering critical insights into the ongoing research and future clinical applications.

The mammalian target of rapamycin (mTOR) is a central node in cell regulation, impacting everything from cellular growth and metabolism to the intricate mechanisms of aging and disease. Its role in the eye, however, is an emerging field that promises to revolutionize our understanding of ocular health and disease.

This book discusses the role of mTOR signaling in the eye. It aims bridge the gap between deep molecular biology and clinical ophthalmology by focusing on the profound effects of mTOR signaling in various parts of the eye. The initial chapters of this book lay the foundational knowledge necessary to understand the complex biology of mTOR, followed by the specific effects on each individual parts of the eye. 

This book is written for researchers, clinicians, and students who are part of a multidisciplinary team striving to push the boundaries of ocular research into mTOR pathways. By the end of this journey, readers will have a comprehensive understanding of the multifaceted roles of mTOR in the eye and the brain, equipped with the knowledge to translate these insights into innovative treatments for ocular and neurodegenerative diseases.

Autor*in

Kambiz Thomas Moazed

Themen in »mTOR Signaling in Ophthalmology«

mTOR signaling pathways mTORC1 mTORC2 PI3K pathway Glaucoma Optic nerve disease Retinal pigment epithelium mTOR Effect on Conjunctiva mTOR Effect on Cornea mTOR Effect on Anterior Segment mTOR Effect on Lens

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