Transposable Elements, Transcriptomics, and Diseases
Buch in deiner Nähe kaufen
Beschreibung
Transposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity.
This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways.
Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines.
Transposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity.
This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways.
Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines.
Provides an in-depth exploration of TEs: from basic biology to therapeutic strategies Emphasizes the critical role of transcriptional and post-transcriptional mechanisms in controlling TE activity Explores the complex interplay between mobile genetic elements and human health
Autor*in
Luis M. Vaschetto
Themen in »Transposable Elements, Transcriptomics, and Diseases«
Genome Evolution Genome Plasticity Genetic Variability Insertional Mutagenesis Long Interspersed Nuclear Element-1 (LINE-1) repeats Mobile Genetic Elements Transposable Elements in Cancer Transposable Elements and Hereditary Diseases Transposable Elements in Neurodegenerative Diseases Epigenetic Control of Transposable Elements