Drug Design and Discovery
Inhibitors of Mitogen-Activated Protein Kinases
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Beschreibung
This book covers the important role small molecules can play in the modulation of stress-activated protein kinase (SAPK), also called the mitogen-activated protein kinase (MAPK) pathway, and the potential this may offer in enabling the development of future medicine therapies. It is clear that MAP kinase pathway therapies could continue to drive increasing interest in the field, both within academic laboratories and also in the biotechnology and pharmaceutical sectors. This book provides an overview of protein kinase inhibitors, the biological roles of MAP kinases, ATP-competitive and non-competitive inhibitors, covalent inhibitors, and more. This book is intended for professors in academia, researchers in pharmaceutical and biotechnology sectors working on protein kinases, and graduate students in pharmacy/chemistry.
This book covers the important role small molecules can play in the modulation of stress-activated protein kinase (SAPK), also called the mitogen-activated protein kinase (MAPK) pathway, and the potential this may offer in enabling the development of future medicine therapies. It is clear that MAP kinase pathway therapies could continue to drive increasing interest in the field, both within academic laboratories and also in the biotechnology and pharmaceutical sectors. This book provides an overview of protein kinase inhibitors, the biological roles of MAP kinases, ATP-competitive and non-competitive inhibitors, covalent inhibitors, and more. This book is intended for professors in academia, researchers in pharmaceutical and biotechnology sectors working on protein kinases, and graduate students in pharmacy/chemistry.
Describes role of small molecules in the modulation of MAPK pathways in the development of future medicine therapies Analyzes recent challenges in designing small molecule inhibitors of MAP kinases Provides examples of successful implementation of MAP kinase inhibitors in clinical trials
Autor*in
Surya K. De
Themen in »Drug Design and Discovery«
Protein Kinase Inhibitors Drug Design Drug Delivery Mitogen-Activated Protein Kinase Inhibitors Clinically Approved Drugs for Protein Kinases ATP-competitive inhibitors Non-ATP site binding inhibitors Bi-dentate inhibitors Covalent inhibitors MAP Kinase signaling network Role of MAPK in obesity and type-2 diabetes Role of MAPK in rheumatoid arthritis Role of MAPK in bronchial asthma Role of MAPK in Parkinson's Disease Role of MAPK in oncology