Role of Autophagy and Reactive Oxygen Species in Cancer Treatment
Principles and Current Strategies
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Beschreibung
Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.
Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.
Highlights the importance of autophagy and reactive oxygen species (ROS) in the treatment of cancer Chapters cover recent accomplishments in the area, ranging from basic concepts to contemporary topics of interest Focuses on innovative strategies for treating different cancer types by using autophagy and multidrug resistance
Autor*in
Neeraj Mishra
Themen in »Role of Autophagy and Reactive Oxygen Species in Cancer Treatment«
Autophagy Reactive Oxygen Species (ROS) Inflammation Oxidative Stress Tumor Metastasis Tumor Progression Anticancer Medication Carcinogenesis Oncogenesis Cancer Immunotherapy Lung Cancer Pancreatic Cancer Liver Cancer Breast Cancer Colorectal Cancer