Human iPSC-derived Disease Models for Drug Discovery

Beschreibung

Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has beenlost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Provides an exhaustive review of use of iPSC in pharmaceutics, iPSC-based modeling and materials science Broadens your understanding of iPSC to model diseases of cardiovascular system, nervous system and ophthalmology Presents iPSC-derived disease models that accelerate the development of pharmacologic treatments

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Markus H. Kuehn

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iPSC disease modeling drug discovery cardiovascular diseases nervous system diseases ophtalmology diseases three-dimensional printing organoids

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