The Quasispecies Equation and Classical Population Models
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Beschreibung
This monograph studies a series of mathematical models of the evolution of a population under mutation and selection. Its starting point is the quasispecies equation, a general non-linear equation which describes the mutation-selection equilibrium in Manfred Eigen’s famous quasispecies model. A detailed analysis of this equation is given under the assumptions of finite genotype space, sharp peak landscape, and class-dependent fitness landscapes. Different probabilistic representation formulae are derived for its solution, involving classical combinatorial quantities like Stirling and Euler numbers.
It is shown how quasispecies and error threshold phenomena emerge in finite population models, and full mathematical proofs are provided in the case of the Wright–Fisher model. Along the way, exact formulas are obtained for the quasispecies distribution in the long chain regime, on the sharp peak landscape and on class-dependent fitness landscapes.
Finally, several other classical population models are analyzed, with a focus on their dynamical behavior and their links to the quasispecies equation.
This book will be of interest to mathematicians and theoretical ecologists/biologists working with finite population models.
This monograph studies a series of mathematical models of the evolution of a population under mutation and selection. Its starting point is the quasispecies equation, a general non-linear equation which describes the mutation-selection equilibrium in Manfred Eigen’s famous quasispecies model. A detailed analysis of this equation is given under the assumptions of finite genotype space, sharp peak landscape, and class-dependent fitness landscapes. Different probabilistic representation formulae are derived for its solution, involving classical combinatorial quantities like Stirling and Euler numbers.
It is shown how quasispecies and error threshold phenomena emerge in finite population models, and full mathematical proofs are provided in the case of the Wright–Fisher model. Along the way, exact formulas are obtained for the quasispecies distribution in the long chain regime, on the sharp peak landscape and on class-dependent fitness landscapes.
Finally, several other classical population models are analyzed, with a focus on their dynamical behavior and their links to the quasispecies equation.
This book will be of interest to mathematicians and theoretical ecologists/biologists working with finite population models.
This book provides an in-depth study of the Eigen's Quasispecies equation in the context of population models. The case of the Wright-Fisher model is treated in detail, other classical population models are also discussed. Contains a foreword by Michel Benaïm.
Autor*in
Raphaël Cerf
Themen in »The Quasispecies Equation and Classical Population Models«
Analysis of Quasispecies equation Manfred Eigen quasispecies model Population models book Mutation-Selection equilibrium analysis Markov chains mathematical biology Wright-Fisher model Long Chain Regime Galton-Watson model biology Population Genetics Moran-Kingman model Raphael Cerf math Joseba Dalmau
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“This book is a welcome and timely addition to the existing literature on rigorous mathematical analysis of various genetics models, with a special focus on a careful understanding of the impact of stochastic effects. The book is written with the potential reader in mind, such that it is a real pleasure to read. It should be interesting to anyone working at the interface of mathematics and population genetics.” (Artem S. Novozhilov, Mathematical Reviews, August, 2023)
“The text is written in an easy-to-read style and is suitable for use in various courses, including probability theory, Markov chains, mathematical ecology and population dynamics. The book can be expected to provide several ideas for further investigation of finite population models.” (Attila Dénes, zbMATH 1507.92072, 2023)
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