Proteinkinase Inhibitors
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Beschreibung
This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.
Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.
Overview chapters introduce the newcomer to the topic covered
Series covers hot topics of frontier research summarized by reputed scientists in the field
Volumes are useful and of relevance for a long period of time
Reviews proteinkinase inhibitors Exploits kinase inhibitors for cancer treatment Offers an authoritative perspective from industry and academia
Autor*in
Stefan Laufer
Themen in »Proteinkinase Inhibitors«
ProteinKinase Receptor Tyrosine Kinases EGFR VEGFR PDGFR Protein Kinase Inhibitors Topology of Proteinkinases c-met MAP-Kinases