Human Population Genomics
Introduction to Essential Concepts and Applications
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Beschreibung
This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields.
Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits.
Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second partcovers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans.This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.
This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields.
Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits.
Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans.This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.
Introduction to population genetics for those without a mathematical background Combining methods and models Explains how population genetics impacts human genetic studies
Autor*in
Kirk E. Lohmueller
Themen in »Human Population Genomics«
Complex Trait Genetics Coalescent Models Demographic History Genetic Association Study Genetic Variation Genome-wide Association Study GWAS Identity by Descent Linkage Disequilibrium Natural Selection Population Genetics
Stimmen zu »Human Population Genomics«
“This book is likely to be most useful to PhD students in the early stages of their graduate degree … . By reading this edited volume, researchers will feel empowered and be able to interpret complex human genomic datasets. … Human Population Genomics: Introduction to Essential Concepts and Applications would be a valuable addition to the bookshelf of any research group that studies this topic.” (Joseph Lachance, The Quarterly Review of Biology, Vol. 97 (3), September, 2022)
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