The Pangenome
Diversity, Dynamics and Evolution of Genomes
Buch in deiner Nähe kaufen
Beschreibung
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications.
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes.
The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory.
Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications.
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes.
The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory.
Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
This open access book covers the fundamental impacts of intra-species genomic diversity Focuses on the evolutionary biology of pan-genomes Elaborates on computational strategies and mathematical models for pan-genome analysis Discusses cutting-edge concepts such as pan-phenomes and pan-epigenomes
Autor*in
Hervé Tettelin
Themen in »The Pangenome«
Comparative genomics Metagenomics Microbial Population Analysis Pangenome Profile Supra-Genome Analysis Adaptive Evolution Computational Tools Bioinformatic Genomics Core Dispensable Genome Selection, Recombination, Composition Acquired Resistance Bacterial Species Concept Genomic Diversity Bacterial Ecology, Microevolution Open Access