Fc Mediated Activity of Antibodies
Structural and Functional Diversity
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Beschreibung
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
Examines the structural diversity of the Fc domain for IgG and IgE Explores the role of Fc receptors in the context of infectious, autoimmune, and neoplastic disorders Provides comprehensive information on Fc receptor pathways as an essential part of the immune response
Autor*in
Jeffrey V. Ravetch
Themen in »Fc Mediated Activity of Antibodies«
autoimmune disorders neoplastic disorders infectious disorders antibody response Fab-antigen interactions antigen recognition infectious diseases