Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Beschreibung
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil Presents an innovative approach, using gold chemistry to target zinc finger proteins Explores the use of Travelling-Wave Ion Mobility coupled with Mass Spectrometry, and X-ray Absorption Spectroscopy to obtain structural information on the Gold adducts
Autor*in
Raphael Enoque Ferraz de Paiva
Themen in »Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins«
Gold Complexes Nucleocapsid Protein NCp7 Human Trabscription Factor Protein 1 Sp1 Zinc Finger Proteins HIV-1 Nucleocapsid Travelling-Wave Ion Mobility Mass Spectrometry X-ray Absorption Spectroscopy Citotoxicity Protein-Ligand Interactions