Modeling Methods for Medical Systems Biology
Regulatory Dynamics Underlying the Emergence of Disease Processes
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Beschreibung
This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progressionof chronic degenerative diseases, using a bottom-up approach.
Offers an empirical-evidence based methodology to describe the dynamical processes underlying chronic diseases from a gene regulatory networks point of view Provides state of the art cases-of-study based on a multi-disciplinary perspective Establishes a bridge between research oriented to the understanding of biological development (morphogenesis and plasticity), and disease emergence due to the disruption of regulatory processes
Autor*in
María Elena Álvarez-Buylla Roces
Themen in »Modeling Methods for Medical Systems Biology«
Morphogenesis Systems dynamics chronic disease degenerative biomolecular immune response regulation Core regulatory networks Systems Biology
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Details
ISBN: 9783030077488
Verlag: Springer International Publishing
Erscheinung: 26.01.2019