A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites
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Beschreibung
This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation.
Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation.
Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.
Nominated as an outstanding Ph.D. thesis by the University of Cambridge Provides a comprehensive, up-to-date database of quantitative composite degradation data mined from existing literature Includes a detailed description of a mathematical modelling framework for the degradation of bioresorbable composites and the analysis of 107 different composite case studies Provides new insights into the interwoven factors controlling degradation
Autor*in
Ismael Moreno-Gomez
Themen in »A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites«
Phenomenological Modelling of Degradation Biodegradable Polymer-Ceramics Composites Tricalcium Phosphate/Hydroxyapatite/Calcium Carbonate Composites Poly(alpha-hydroxy-acids) Composites Degradation Mechanisms in Vivo