Life-Span Extension
Single-Cell Organisms to Man
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Beschreibung
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.
Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.
Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.
Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.
Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.
Multidisciplinary, with viewpoints of experts studying the aging process in species ranging from yeast to man Discusses identification of common pathways that modulate longevity Provides overview of recent, remarkable discoveries about underlying mechanisms important to aging Explore studies in humans that have identified potentially important markers for successful aging Discusses single mutations that extend life span and have been identified in yeast, worms, flies, and mice Outlines emerging technologies and wide variety of systems that are now used to study aging
Autor*in
Christian Sell
Themen in »Life-Span Extension«
Caenorhabditis elegans Life span Life-span extension Longevity Mammals Markers Neuroendocrine pathways Single mutations Species Stress response Yeast aging insulin/insulin-like growth factor (IGF) pathways mTOR pathway
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From the reviews:
“This multiauthored book reviews the mechanisms of life-span extension across the animal kingdom, including man. … The audience here is researchers into the nature of aging and longevity. Many scientists looking at redox reactions in the body find themselves ultimately researching the nature of aging. For them, this is a useful guide. … This compact, well-edited book is a timely review of a complex subject.” (David O. Staats, Doody’s Review Service, April, 2010)
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